I’ve been working on a Adobe Lightroom plugin, Dossier de Presse, for a while now, to directly publish photos into galleries, using NextGEN gallery (or alternatively into WordPress media library). It’s based on XMLRPC communication between Adobe Lightroom and your WordPress site.
One can create a post associated with the gallery. It’s still pretty rough (especially in case of errors), but it should work on Mac and Windows.
At this point, the image resolution is limited to 300×300 pixels, during the testing phase.
Find all the information at this page : http://luc.lakephoto.org/journal/dossier-de-presse/
If you use it, please post a comment or send me a note at “luc at lakephoto dot org”, I’d appreciate it.